WEIGHT-BASED HEPARIN DOSING

INITIAL THERAPY - Bolus 60-80 units/ Kg
- Infusion 14-18 units/kg/hr

ADJUSTMENTS

aPTT<40 - 2000 units IV bolus, increase infusion by 2 units/kg/hr aPTT 40-44 - increase infusion by 1 unit/kg/hr aPTT 45-70 - no change aPTT 71-80 - decrease infusion by 1 unit/kg/hr aPTT 81-90 - hold for 0.5 hour - decrease infusion by 2 units/kg/hr aPTT >90 - hold for 1 hour
- decrease infusion by 3 units/kg/hr

NOTE: drain aPTT 6 hours after any bolus or change in infusion rate